Early Coagulopathy in Trauma Study

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Life-threatening bleeding is caused by a combination of vascular (vessels carrying fluid) injury and a defect in the body's clotting mechanism, referred to as coagulopathy.  This kind of bleeding accounts for a substantial proportion of mortality in trauma patients. About one quarter of poly traumatized patients are coagulopathic on hospital presentation. This has been shown to be independently associated with a 4-fold increase in mortality.  

While current resuscitation practices are aimed at stopping bleeding through “damage control surgery,” the specific management of coagulopathy has been relatively neglected with treatment of coagulopathy assumed to be a byproduct of blood product administration, management of hypothermia and surgical cessation of bleeding.

It has been recently shown that acute coagulopathy can be predicted by a score calculated from simple, routinely measured pre-hospital parameters (vital signs, injuries and interventions). Early prediction of coagulopathy may be used to identify patients at a high risk of uncontrollable haemorrhage who would benefit from early, directed management of coagulopathy.
 
Avoiding, or minimising the early coagulopathy of trauma requires an understanding of the biological process involved in the development of the condition, the ability to predict or detect patients at risk, and practical and appropriately directed interventions capable of inhibiting or reversing the process at play.

This project aims to:

  • Investigate the characteristics, timing and predictability of early coagulopathy in trauma.
  • Based on the analysis of data, plan and undertake a trial of pre hospital intervention in affected patients to avoid or minimise development of coagulopathy of trauma. 

If you would like more information or are interested in the participating in the Early Coagulopathy in Trauma Study please click here